What it is
Clearesterol (the active ingredient) is the manufacturer’s name for tocotri-enols extracted from rice bran. Tocotrienols are a special form of vitamin E that acts as an HMG-CoA reductase inhibitor, damping cholesterol production. (Alpha-tocopherol, the form of vitamin E in vitamin E supplements, has no effect on cholesterol levels.)
What research shows
An unpublished study sponsored by Bionutrics showed that people taking 50 mg of rice bran tocotrienol (there are 25 mg in one EvolvE capsule) had a drop in LDL cholesterol of about 21% in five weeks. In the single published study, however, 20 people had a 16% reduction when they took 178 mg tocotrienols for four weeks. James Anderson, MD, cholesterol expert at the University of Kentucky in Lexington, says, “Tocotrienols probably work, but we don’t have a clue yet as to how much you need.”
If you take vitamin E supplements, be aware that the vitamin may reduce EvolvE’s cholesterol-cutting effect. But don’t stop taking vitamin E, warns William Castelli, MD, director of the Framingham (MA) Cardiovascular Institute: “It has a proven outcomes benefit: fewer heart attacks.”
EvolvE’s recommended dosage is one or two 25 mg capsules daily. A month’s supply of one daily capsule costs approximately $13.