Synthetic vs. leather sneakers

What are the benefits of a synthetic/mesh construction compared to a leather/mesh walking shoe, besides weight?

Leather shoes may be more durable and may keep moisture (like dew or rain) out a little bit better. They may hold their shape a little bit better. As for synthetic shoes, depending on the material, they may breathe better. I also find that my leather walking shoes stay cleaner looking a little bit longer.

Any other opinions?┬áSome people just like leather – the smell, the fit, the feel – over synthetic materials.

What you have in your mind?